UW-CTRI has expanded the understanding of tobacco dependence and its treatment, and has used this knowledge to design and implement interventions that have significantly reduced tobacco use in Wisconsin and across the globe. This, in turn, has eased the burdens of disease, death, and health-care costs in Wisconsin. UW-CTRI has: • Published more than 380 research articles. • Helped more than 200,000 smokers to quit. • Generated more than $111 million in grant funding. • Created the No. 1 Web site for tobacco research listed on Google. • Augmented the way health-care systems approach tobacco treatment to help more patients quit smoking. Future goals include matching tailored treatments to individual patients.